MyBioSource.com's SAPK/JNK (Phospho-Thr183) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The SAPK/JNK (Phospho-Thr183) Antibody was generated using JNK-55, Protein Kinase, and SAPK as the antigen and it reacts with Human, Mouse, and Rat.
Description
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells